(stron' shee um)

Brand Name(s): Metastron^®

WHY is this medicine prescribed?

Your doctor has ordered the drug strontium-89 chloride to help treat your illness. The drug is given by injection into a vein or a catheter that has been placed in a vein.

This medication is used to:

• relieve bone pain

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Strontium-89 chloride is in a class of drugs known as radioisotopes. It delivers radiation to cancer sites and ultimately decreases bone pain. The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer you have.

What SPECIAL PRECAUTIONS should I follow?

Before taking strontium-89 chloride,

• tell your doctor and pharmacist if you are allergic to strontium-89 chloride or any other drugs.

• Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.

• The following nonprescription product may interact with strontium-89 chloride: aspirin. Be sure to let your doctor and pharmacist know that you are taking this medication before you start taking strontium-89 chloride. Do not start this medication while taking strontium-89 chloride without discussing with your healthcare provider..

• tell your doctor if you have or have ever had bone marrow disease, blood disorders, or kidney disease.

• you should know that strontium-89 chloride may interfere with the normal menstrual cycle (period) in women and may stop sperm production in men. However, you should not assume that you cannot get pregnant or that you cannot get someone else pregnant. Women who are pregnant or breast-feeding should tell their doctors before they begin taking this drug. You should not plan to have children while receiving chemotherapy or for a while after treatments. (Talk to your doctor for further details.) Use a reliable method of birth control to prevent pregnancy. Strontium-89 chloride may harm the fetus.

• notify any health care professional (especially other doctors) giving you treatment that you will be taking strontium-89 chloride.

• do not have any vaccinations (e.g., measles or flu shots) without talking to your doctor.

What SIDE EFFECTS can this medicine cause?

Side effects from strontium-89 chloride are common and include:

• increased pain starting 2 to 3 days after treatment and lasting 2 to 3 days
• flushing
• diarrhea

Tell your doctor if the following symptom is severe or lasts for several hours:

• fatigue

If you experience any of the following symptoms, call your doctor immediately:

• unusual bruising or bleeding
• no decrease in pain 7 days after treatment
• fever
• chills

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What OTHER INFORMATION should I know?

• Because this medication may be present in your blood and urine for about 1 week after an injection, you should follow certain precautions during this time. Use a normal toilet instead of a urinal, if possible, and flush the toilet twice after each use. Also wash your hands with soap and water after using the toilet. Wipe any spilled urine or blood with a tissue and flush the tissue away. Immediately wash any stained clothes or bed linens separately from other laundry.
• The most common side effect of strontium-89 chloride is a decrease of blood cells. Your doctor may order tests before, during, and after your treatment to see if your blood cells are affected by the drug.

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS^® Patient Medication Information™. © Copyright, 2024. The American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: June 20, 2024.