(fen ox ee ben' za meen)

Brand Name(s): Dibenzyline^®; also available generically

WHY is this medicine prescribed?

Phenoxybenzamine is used to treat episodes of high blood pressure and sweating related to pheochromocytoma.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Are there OTHER USES for this medicine?

Phenoxybenzamine is also used to control bladder problems such as urgency, frequency, and inability to control urination in patients with neurogenic bladder, functional outlet obstruction, and partial prostatic obstruction. Talk to your doctor about the possible risks of using this drug for your condition.

HOW should this medicine be used?

Phenoxybenzamine comes as a capsule to take by mouth. It usually is taken two or three times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take phenoxybenzamine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Phenoxybenzamine controls symptoms related to pheochromocytoma and controls bladder symptoms but does not cure them. Continue to take phenoxybenzamine even if you feel well. Do not stop taking phenoxybenzamine without talking to your doctor.

What SPECIAL PRECAUTIONS should I follow?

Before taking phenoxybenzamine,

• tell your doctor and pharmacist if you are allergic to phenoxybenzamine or any other drugs.

• tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially medications for diet control, high blood pressure, asthma, cough, colds, allergies, and glaucoma; and vitamins.

• tell your doctor if you have or have ever had heart or kidney disease, a stroke, or transient ischemic attacks (TIA).

• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking phenoxybenzamine, call your doctor immediately.

• you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.

• remember that alcohol can add to the drowsiness caused by this drug.

What should I do IF I FORGET to take a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What SIDE EFFECTS can this medicine cause?

Phenoxybenzamine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• nasal congestion
• dizziness
• upset stomach
• sexual dysfunction (difficulty ejaculating)
• dizziness

If you experience any of the following symptoms, call your doctor immediately:

• fainting
• fast heartbeat
• vomiting

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your blood pressure should be checked regularly to determine your response to phenoxybenzamine.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS^® Patient Medication Information™. © Copyright, 2024. The American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: April 15, 2017.